Arghavan Farzadi; Mehran Solati Hashjin; Farhad Bakhshi; Alie Aminian
Volume 5, Issue 3 , June 2011, , Pages 206-213
Abstract
Using microwave irradiation in microwave-assisted synthesis method is a new approach employed to decrease synthesis time and to form more homogenous structures of biphasic calcium phosphate bioceramics. In this research, the microwave assisted synthesis and characterization of biphasic calcium phosphate ...
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Using microwave irradiation in microwave-assisted synthesis method is a new approach employed to decrease synthesis time and to form more homogenous structures of biphasic calcium phosphate bioceramics. In this research, the microwave assisted synthesis and characterization of biphasic calcium phosphate nanopowders have been studied. The phase transformation, chemical components, morphology and particle size were characterized by X-Ray Diffraction (XRD) analysis, Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The results showed that the use of microwave led to improve crystallinity and the crystallite size increases from 16 nm to 27 nm. Also the amount of hydroxyapatite phase in biphasic calcium phosphate changed in the range of 5% to 17%. The prepared sample was put in Simulated Body Fluid (SBF).The pH of the solution was decreased in the present of beta-tricalcium phosphate showed its biodegradable behavior. Also the nucleation and growth of hydroxyapatite particles on TCP produced by microwave -assisted synthesis method changed to be rod like in SBF solution.
Targeted Drug Delivery / Smart Drug Delivery / Drug Targeting
Seyede Sara Shafiei; Mehran Solati Hashjin; Mehrnaz Salarian
Volume 3, Issue 2 , June 2009, , Pages 119-125
Abstract
Layered double hydroxides (LDHs) are layered solid materials having positively charged layers. A variety of negatively charged biomolecules can be hybridized with LDHs to evolve into bio-LDH Nano hybrids, including vitamins, drugs and DNA strands as well as simple organic acids. In this research, Mg-Al-LDH ...
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Layered double hydroxides (LDHs) are layered solid materials having positively charged layers. A variety of negatively charged biomolecules can be hybridized with LDHs to evolve into bio-LDH Nano hybrids, including vitamins, drugs and DNA strands as well as simple organic acids. In this research, Mg-Al-LDH containing drug was synthesized by coprecipitation and anion exchange methods. The LDH structure was characterized by X-Ray Diffraction XRD, FTIR, SEM and STA techniques. The in vitro release profile of nano hybrids was analyzed by UV spectrophotometer. It was concluded that the present biocompatible hydrotalcite-like compound can be an excellent host material for encapsulating Ibuprofen and can play a role as a delivery vehicle for a controlled release.
Biomechanics of Bone / Bone Biomechanics
Seyed Mahmoud Rabiei; Fathollah Moztarzadeh; Mehran Solati Hashjin; Saeed Hesaraki
Volume 1, Issue 2 , June 2007, , Pages 105-110
Abstract
In this research, the influence of NaH2PO4.2H2O with different concentrations on setting time and compressive strength of bone cement based on hydroxyapatite was investigated. Hydroxyapatite cement is of calcium phosphate bone cements, which can be considered as the best substitute for hard tissues. ...
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In this research, the influence of NaH2PO4.2H2O with different concentrations on setting time and compressive strength of bone cement based on hydroxyapatite was investigated. Hydroxyapatite cement is of calcium phosphate bone cements, which can be considered as the best substitute for hard tissues. The powder phase of the cement was prepared from various compositions of calcium phosphates such: tricalcium phosphate (TCP), calcium carbonate (CaCO3) and montite (CaHPO4) as constant and the liquid part using NaH2PO4.2H2O solution with different concentrations. The influences of liquid/powder ratio L/P (ml/g) was investigated on the initial and final setting times and compressive strengths of the cement. According to the obtained results, with optimum concentrations of the liquid phase, this cement seems suitable for clinical applications.
